OPRS1 (N-term) Peptide
产品名称： OPRS1 (N-term) Peptide
英文名称： OPRS1 (N-term) Peptide
产品编号： P1236
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
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- 邮编 : 11493
- 所在区域 : 台湾
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- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of OPRS1.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human OPRS1.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Ammonium sulfate precipitation
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:50-100)
Flow cytometry (1:10-50)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- An unambiguous assay for the cloned human sigma1 receptor reveals high affinity interactions with dopamine D4 receptor selective compounds and a distinct structure-affinity relationship for butyrophenones.
Lee IT, Chen S, Schetz JA.Eur J Pharmacol. 2008 Jan 14;578(2-3):123-36. Epub 2007 Oct 2.
- 2.
- Irreversible blockade of sigma-1 receptors by haloperidol and its metabolites in guinea pig brain and SH-SY5Y human neuroblastoma cells.
Cobos EJ, del Pozo E, Baeyens JM.J Neurochem. 2007 Aug;102(3):812-25. Epub 2007 Apr 10.
- 3.
- Neuro(active)steroids actions at the neuromodulatory sigma1 (sigma1) receptor: biochemical and physiological evidences, consequences in neuroprotection.
Maurice T, Gregoire C, Espallergues J.Pharmacol Biochem Behav. 2006 Aug;84(4):581-97. Epub 2006 Sep 1.
- Entrez GeneID:
- 10280
- Protein Accession#:
- NP_005857;Q99720
- Gene Name:
- SIGMAR1
- Gene Alias:
- FLJ25585,MGC3851,OPRS1,SR-BP1
- Gene Description:
- sigma non-opioid intracellular receptor 1
- Omim ID:
- 601978
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a receptor protein that interacts with a variety of psychotomimetic drugs, including cocaine and amphetamines. The receptor is believed to play an important role in the cellular functions of various tissues associated with the endocrine, immune, and nervous systems. As indicated by its previous name, opioid receptor sigma 1 (OPRS1), the product of this gene was erroneously thought to function as an opioid receptor; it is now thought to be a non-opioid receptor. Alternative splicing of this gene results in transcript variants encoding distinct isoforms. [provided by RefSeq
- Other Designations:
- OTTHUMP00000000515,OTTHUMP00000000516,OTTHUMP00000000517,OTTHUMP00000021286,SR31747 binding protein 1,aging-associated gene 8 protein,opioid receptor, sigma 1,sigma1 receptor,type I sigma receptor
- Related Disease
- Alcoholism
- Alzheimer Disease
- Alzheimer disease
- Amphetamine-Related Disorders
- Anorexia Nervosa
- Bulimia
- Cerebral Amyloid Angiopathy
- Cognition
- Cognition Disorders
- Depressive Disorder, Major
- Genetic Predisposition to Disease
- Neuroblastoma
- Neuropsychological Tests
- Personality Disorders
- Psychiatric Status Rating Scales
- Schizophrenia
- Schizophrenia
- Schizophrenia, Disorganized
- Schizophrenia, Paranoid